Nutrobal (Mk-677) is a potent growth hormone (GH) secretagogue, which mimics GH’s stimulating action of ghrelin – an endogenous hormone. It has been studied over the past decade for the treatment of low levels of IGF-1, as well as growth hormone deficiencies in children and elderly adults. Interestingly, nutrobal has the advantage of being safer and less expensive than growth hormone.
Nowadays, athletes have started utilizing this potent compound as a performance enhancer to improve endurance, fat loss, and gaining muscle mass.
How mk-677 works ?
Growth hormone pulse intensity can be increased through 4 possible mechanisms:
Increasing GHRH (growth hormone releasing hormone) release.
Amplifying GHRH signaling in somatotrophs of the anterior pituitary gland.
Reducing somatostatin release (somatostatin turns off GH release).
Inhibiting of somatostatin receptor signaling.
Nutrobal (Mk-677) was found to work through all four of these mechanisms. After ingestion, Growth Hormone (GH) was shown to increase dose dependently, at doses starting at 5 milligrams (mgs) a day.
MK-677 Ibutamoren Mesylate Powder Benefits:
In a study on it’s effects on catabolic states, a once daily oral dose of 25mgs was given to healthy young men subjected to short-term diet-induced nitrogen wasting. After 7 days of this dose, the subjects showed a sustained increase in serum concentration of IGF-1 and Growth Hormone; in addition, the nitrogen wasting was reversed, showing great potential for treatment of conditions involving muscle wasting.
Trials testing the effects of this GHS on fighting obesity showed an increase in lean body mass, but neither total, nor visceral adipose tissue was effected. This study gave subjects 25mgs of Nutrobal per day for 8 weeks. The subjects showed an increase in basal metabolic rate after 2 weeks, and an increase in serum levels of GH, IGF-1 and IGF-1 binding protein-3. Increase in lean body mass was hypothesized to be caused by an increase in calorie deposition into the muscle and appetite decrease as opposed to reducing fat storage directly.
A study done for the treatment of osteoporosis and bone mineral density showed some increase in bone density, so there is a true impact on bone mineral density. This can help with injury recovery during your cycle.
Other possible benefits of Nutrobal are associated with improved sleep, improved complexion, increase in energy levels, increase nitrogen retention, increase strength and an improved sense of well being. In addition, some studies also suggest that an increased immune system response was caused by Nutrobal (Mk-677), meaning it boosts the immune system to a degree.
MK-677 Ibutamoren Mesylate Powder Doses:
Results have been shown from doses between 5-25mgs a day, dose dependent results should be expected. Higher doses, over 50mgs, have been reported by some, but I don’t see the need to overdo it.
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